menF [2017-8-11 16:0:3]

menaquinone-specific isochorismate synthase

locus: BSU30830

pI: 4.71

mw: 52.65 kDa

protein length: 471 aa

gene length: 1413 bp

function: biosynthesis of menaquinone

product: menaquinone-specific isochorismate synthase

essential: no

ec: 5.4.4.2

synonyms: icsM, entC

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.8|Biosynthesis of menaquinone]

Gene

Coordinates: 3,152,302 → 3,153,717

The protein

Catalyzed reaction/ biological activity

• Chorismate = isochorismate (according to Swiss-Prot)

Protein family

• isochorismate synthase family (according to Swiss-Prot)

Structure

• [PDB|3BZM] (from ''Escherichia coli'', 33% identity, 51% similarity) [Pubmed|18453696]

Expression and Regulation

Operons

• genes: [gene|8EFE4D2B07E54A0EE7D6821C9FEBFC7DC22FDE03|menF]-[gene|E3283812B7EB374EAC8722ECCE28432DE24B7B4C|menD]-[gene|74659B6794496912E139B3CF9EFF787B63729A3F|ytxM]-[gene|224584953B0BC1AF666CD69372B2D53AC56F6752|menB]-[gene|16412BAB04BBF9FD1C3653328923687874C81868|menE]-[gene|9B2F45BC37D4F356B366447A33DC95639EF484EE|menC]
  description: [Pubmed|9387221,1629163,8550504]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8550504], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  additional information

  • A [protein|search|ncRNA] is predicted between '[protein|search|mntA]' and '[protein|search|menC]' [PubMed|20525796]

References

• 9387221,1629163,8550504